O que significa Too glam to give a damn ?

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"glam" can be used as an adjective, it comes from the French "glamour" and is related to the English "glimmer" which means to sparkle or twinkle whilst shining. You can often see it to describe jewels or lights and their respective shine. When someone says they're "glam" or uses it in any way, it's to imply a certain shine but moreso in character, charisma, appeal, beauty, brilliance and such.

To be "too glam to give a damn" is to be someone who is far too fabulous, thriving, beautiful, stylish, etc. to care about anything negative or criticism, typically.

You have another expression that gives a similar idea: "I'm too cool for school." obviously this is bad when translated directly, but it's not supposed to have a literal meaning. It just means that you're way above something else.